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1

The physical characterisation of a microscale parallel bioreactor platform with an industrial CHO cell line expressing an IgG4

Nienow, Alvin W., Rielly, Christopher D., Brosnan, Kathryn, Bargh, Neil, Lee, Kenneth, Coopman, Karen, Hewitt, Christopher J.

Journal:

Biochemical Engineering Journal

Year:

2013

Language:

english

File:

PDF, 2.45 MB

english, 2013

2

Homogenisation and oxygen transfer rates in large agitated and sparged animal cell bioreactors: Some implications for growth and production

Alvin W. Nienow, Christian Langheinrich, Neil C. Stevenson, A Nicholas Emery, Timothy M. Clayton, Nigel K. H. Slater

Journal:

Year:

1996

Language:

english

File:

PDF, 609 KB

english, 1996

3

A potentially scalable method for the harvesting of hMSCs from microcarriers

Nienow, Alvin W., Rafiq, Qasim A., Coopman, Karen, Hewitt, Christopher J.

Journal:

Biochemical Engineering Journal

Year:

2014

Language:

english

File:

PDF, 3.14 MB

english, 2014

4

Control of pH in large-scale, free suspension animal cell bioreactors: Alkali addition and pH excursions

Christian Langheinrich, Alvin W. Nienow

Journal:

Biotechnology and Bioengineering

Year:

1999

Language:

english

File:

PDF, 197 KB

english, 1999

5

Lagrangian tools for the analysis of mixing in single-phase and multiphase flow systems

Antonio Guida, Alvin W. Nienow, Mostafa Barigou

Journal:

Year:

2012

Language:

english

File:

PDF, 1.47 MB

english, 2012

6

Gas—liquid mixing studies with multiple up- and down-pumping hydrofoil impellers: Power characteristics and mixing time

Danawati Hari-Prajitno, Ved P. Mishra, Katsuhide Takenaka, Waldemar Bujalski, Alvin W. Nienow, Jack Mckemmie

Journal:

The Canadian Journal of Chemical Engineering

Year:

1998

Language:

english

File:

PDF, 1.25 MB

english, 1998

7

The Use of Phase Inversion Temperature (PIT) Microemulsion Technology to Enhance Oil Utilisation duringStreptomyces rimosusFed-batch Fermentations to Produce Oxytetracycline

Panos A. Papapanagiotou, Henry Quinn, Jean-Pierre Molitor, Alvin W. Nienow, Christopher J. Hewitt

Journal:

Biotechnology Letters

Year:

2005

Language:

english

File:

PDF, 256 KB

english, 2005

8

Basic bioreactor design: Bioreactors in Biotechnology: A Practical Approach edited by A. J. Scragg, Ellis Harwood, 1991. UK£59.00 (330 pages) ISBN 0 13 085143 4

Alvin W. Nienow

Journal:

Trends in Biotechnology

Year:

1993

Language:

english

File:

PDF, 216 KB

english, 1993

9

Scale-down studies for assessing the impact of different stress parameters on growth and product quality during animal cell culture

Nienow, Alvin W., Scott, William H., Hewitt, Christopher J., Thomas, Colin R., Lewis, Gareth, Amanullah, Ashraf, Kiss, Robert, Meier, Steven J.

Journal:

Chemical Engineering Research and Design

Year:

2013

Language:

english

File:

PDF, 1.34 MB

english, 2013

10

Stirring and Stirred-Tank Reactors

Nienow, Alvin W.

Journal:

Chemie Ingenieur Technik

Year:

2014

Language:

english

File:

PDF, 943 KB

english, 2014

11

Scale-Up Considerations Based on Studies at the Bench Scale in Stirred Bioreactors

Nienow, Alvin William

Journal:

JOURNAL OF CHEMICAL ENGINEERING OF JAPAN

Year:

2009

Language:

english

File:

PDF, 82 KB

english, 2009

12

Further studies related to the scale-up of high cell density escherichia coli fed-batch fermentations: : The additional effect of a changing microenvironment when using aqueous ammonia to control pH

Helen Onyeaka, Alvin W. Nienow, Christopher J. Hewitt

Journal:

Biotechnology and Bioengineering

Year:

2003

Language:

english

File:

PDF, 384 KB

english, 2003

13

Bubble sizes in agitated solvent/reactant mixtures used in heterogeneous catalytic hydrogenation of 2-butyne-1,4-diol

Binjie Hu, Alvin W. Nienow, E. Hugh Stitt, Andrzej W. Pacek

Journal:

Chemical Engineering Science

Year:

2006

Language:

english

File:

PDF, 500 KB

english, 2006

14

Shannon entropy for local and global description of mixing by Lagrangian particle tracking

Antonio Guida, Alvin W. Nienow, Mostafa Barigou

Journal:

Chemical Engineering Science

Year:

2010

Language:

english

File:

PDF, 1.56 MB

english, 2010

15

Mixing in large-scale vessels stirred with multiple radial or radial and axial up-pumping impellers: modelling and measurements

Peter Vrábel, Rob G.J.M van der Lans, Karel Ch.A.M Luyben, Lotte Boon, Alvin W Nienow

Journal:

Chemical Engineering Science

Year:

2000

Language:

english

File:

PDF, 622 KB

english, 2000

16

PEPT measurements of solid–liquid flow field and spatial phase distribution in concentrated monodisperse stirred suspensions

Antonio Guida, Alvin W. Nienow, Mostafa Barigou

Journal:

Chemical Engineering Science

Year:

2010

Language:

english

File:

PDF, 1.38 MB

english, 2010

17

Mixing studies in a model aerated bioreactor equipped with an up- or a down-pumping ‘Elephant Ear’ agitator: Power, hold-up and aerated flow field measurements

Hui Zhu, Alvin W. Nienow, Waldek Bujalski, Mark J.H. Simmons

Journal:

Chemical Engineering Research and Design

Year:

2009

Language:

english

File:

PDF, 2.70 MB

english, 2009

18

Mixing by rotary jet heads: Indications of the benefits of head rotation under turbulent and transitional flow conditions

Mikkel Nordkvist, Marie Vognsen, Alvin W. Nienow, John Villadsen, Krist V. Gernaey

Journal:

Chemical Engineering Research and Design

Year:

2008

Language:

english

File:

PDF, 2.50 MB

english, 2008

19

Scale-down/scale-up studies leading to improved commercial beer fermentation

Dr. Alvin W. Nienow, Mikkel Nordkvist, Christopher A. Boulton

Journal:

Biotechnology Journal

Year:

2011

Language:

english

File:

PDF, 586 KB

english, 2011

20

The scale-up of microbial batch and fed-batch fermentation processes

Christopher Hewitt, Alvin Nienow

Journal:

Journal of Biotechnology

Year:

2007

Language:

english

File:

PDF, 81 KB

english, 2007

21

Culture of human mesenchymal stem cells on microcarriers in a 5

Rafiq, Qasim A., Brosnan, Kathryn M., Coopman, Karen, Nienow, Alvin W., Hewitt, Christopher J.

Journal:

Biotechnology Letters

Year:

2013

Language:

english

File:

PDF, 1.04 MB

english, 2013

22

Impeller Power Numbers in Closed Vessels

Nienow, Alvin W., Miles, David

Journal:

Industrial & Engineering Chemistry Process Design and Development

Year:

1971

Language:

english

File:

PDF, 319 KB

english, 1971

23

Re “Development of a scale-down model of hydrodynamic stress to study the performance of an industrial CHO cell line under simulated production scale bioreactor conditions” [Sieck, J.B., Cordes, T., Budach, W.E., Rhiel, M.H., Suemeghy, Z., Leist, C., Villiger, T.K., Morbidelli, M., Soos, M., 2013. Journal of Biotechnology 164, 41–49]

Nienow, Alvin W.

Journal:

Journal of Biotechnology

Year:

2014

Language:

english

File:

PDF, 405 KB

english, 2014

24

Agitation conditions for the culture and detachment of hMSCs from microcarriers in multiple bioreactor platforms

Nienow, Alvin W., Hewitt, Christopher J., Heathman, Thomas R.J., Glyn, Veronica A.M., Fonte, Gonҫalo N., Hanga, Mariana P., Coopman, Karen, Rafiq, Qasim A.

Journal:

Biochemical Engineering Journal

Year:

2015

Language:

english

File:

PDF, 721 KB

english, 2015

25

Bubble size distributions in impeller region in a gas-sparged vessel agitated by a Rushton turbine.

Takahashi, Koji, McManamey, William J., Nienow, Alvin W.

Journal:

JOURNAL OF CHEMICAL ENGINEERING OF JAPAN

Year:

1992

File:

PDF, 3.24 MB

1992

26

Mixing of Three-Phase Systems at High Solids Content (up to 40% w/w) Using Radial and Mixed Flow Impellers.

TAKENAKA, KATSUHIDE, CIERVO, GIOVANNA, MONTI, DAVIDE, BUJALSKI, WALDEMAR, ETCHELLS, ARTHUR W., NIENOW, ALVIN W.

Journal:

JOURNAL OF CHEMICAL ENGINEERING OF JAPAN

Year:

2001

Language:

english

File:

PDF, 94 KB

english, 2001

27

The Impact of Fluid Dynamic Stress in Stirred Bioreactors â The Scale of the Biological Entity: A Personal Viewâ

Nienow, Alvin W.

Journal:

Chemie Ingenieur Technik

Year:

2020

File:

PDF, 4.93 MB

2020

28

The use of flow cytometry to study the impact of fluid mechanical stress on Escherichia coli W3110 during continuous cultivation in an agitated bioreactor

Christopher J. Hewitt, Lotte A. Boon, Caroline M. McFarlane, Alvin W. Nienow

Journal:

Biotechnology and Bioengineering

Year:

1998

Language:

english

File:

PDF, 499 KB

english, 1998

29

Study of drop and bubble sizes in a simulated mycelial fermentation broth of up to four phases

Enrique Galindo, Andrzej W. Pacek, Alvin W. Nienow

Journal:

Biotechnology and Bioengineering

Year:

2000

Language:

english

File:

PDF, 316 KB

english, 2000

30

Studies related to the scale-up of high-cell-density E. coli fed-batch fermentations using multiparameter flow cytometry: Effect of a changing microenvironment with respect to glucose and dissolved oxygen concentration

Christopher J. Hewitt, Gerhard Nebe-Von Caron, Britta Axelsson, Caroline M. McFarlane, Alvin W. Nienow

Journal:

Biotechnology and Bioengineering

Year:

2000

Language:

english

File:

PDF, 650 KB

english, 2000

31

Mixing of dense binary suspensions: Multi-component hydrodynamics and spatial phase distribution by PEPT

Antonio Guida, Alvin W. Nienow, Mostafa Barigou

Journal:

Year:

2011

Language:

english

File:

PDF, 2.82 MB

english, 2011

32

Operational intensification by direct product sequestration from cell disruptates: Application of a pellicular adsorbent in a mechanically integrated disruption-fluidised bed adsorption process

Mohsen Jahanshahi, Yan Sun, Everaldo Santos, Andrzej Pacek, Telma Teixera Franco, Alvin Nienow, Andrew Lyddiatt

Journal:

Biotechnology and Bioengineering

Year:

2002

Language:

english

File:

PDF, 297 KB

english, 2002

33

A comparison of high cell density fed-batch fermentations involving both induced and non-induced recombinant Escherichia coli under well-mixed small-scale and simulated poorly mixed large-scale conditions

Christopher J. Hewitt, Helen Onyeaka, Gareth Lewis, Ian W. Taylor, Alvin W. Nienow

Journal:

Biotechnology and Bioengineering

Year:

2007

Language:

english

File:

PDF, 534 KB

english, 2007

34

Mixing Studies Related to the Cleaning of Molten Aluminium

M. Kimata, N. Nayan, W. Bujalski, Alvin W. Nienow, J.L. Song, M.R. Jolly

Journal:

Chemical Engineering & Technology

Year:

2004

Language:

english

File:

PDF, 183 KB

english, 2004

35

Performance of the scaba 6SRGT agitator in mixing of simulated xanthan gum broths

Dr. Enrique Galindo, Prof. Alvin W. Nienow

Journal:

Chemical Engineering & Technology

Year:

1993

Language:

english

File:

PDF, 573 KB

english, 1993

36

Ein neuer, axial fördernder Rührer zum Dispergieren von Gas in Flüssigkeiten

Volker C. Haß, Prof. Dr. Alvin W. Nienow

Journal:

Chemie Ingenieur Technik

Year:

1989

Language:

german

File:

PDF, 328 KB

german, 1989

37

Micromixing in two-phase (G-L and S-L) systems in a stirred vessel

Julia Hofinger, Robert W. Sharpe, Waldemar Bujalski, Serafim Bakalis, Melissa Assirelli, Archie Eaglesham, Alvin W. Nienow

Journal:

The Canadian Journal of Chemical Engineering

Year:

2011

Language:

english

File:

PDF, 303 KB

english, 2011

38

Ingénierie du mélange: État actuel de la recherche préambule

Philippe A. Tanguy, Alvin W. Nienow

Journal:

The Canadian Journal of Chemical Engineering

Year:

1998

Language:

french

File:

PDF, 123 KB

french, 1998

39

Engineering research on mixing: State of the art introductory remarks

Philippe A. Tanguy, Alvin W. Nienow

Journal:

The Canadian Journal of Chemical Engineering

Year:

1998

Language:

english

File:

PDF, 107 KB

english, 1998

40

Scale-up of mixing in gassed multi-turbine agitated vessels

Jorge M. T. Vasconcelos, Sebastião S. Alves, Alvin W. Nienow, Waldemar Bujalski

Journal:

The Canadian Journal of Chemical Engineering

Year:

1998

Language:

english

File:

PDF, 772 KB

english, 1998

41

A study of an up- and a down-pumping wide blade hydrofoil impeller: Part I. LDA measurements

Ved P. Mishra, Kate N. Dyster, Alvin W. Nienow, Jack Mckemmie, Zdzislaw Jaworski

Journal:

The Canadian Journal of Chemical Engineering

Year:

1998

Language:

english

File:

PDF, 1.01 MB

english, 1998

42

A study of an up- and a down-pumping wide-blade hydrofoil impeller: Part II. CFD analysis

Zdzislaw Jaworski, Kate N. Dyster, Ved P. Mishra, Alvin W. Nienow, Miroslaw L. Wyszynski

Journal:

The Canadian Journal of Chemical Engineering

Year:

1998

Language:

english

File:

PDF, 1.07 MB

english, 1998

43

Instabilities when using a standard (T/3) rushton turbine for stirring as foam disruption (SAFD)

Lotte A. Boon, Waldemar Bujalski, Alvin W. Nienow, Frans W.J.M.M. Hoeks, Rob G.J.M. Van Der Lans

Journal:

The Canadian Journal of Chemical Engineering

Year:

2000

Language:

english

File:

PDF, 778 KB

english, 2000

44

Some Effects of Particle Wettability in Agitated Solid-Gas-Liquid Systems: Gas-Liquid Mass Transfer and the Dispersion of Floating Solids

Fabio Gentile, Holger Oleschko, Premek Veverka, Vaclav Machoň, Alessandro Paglianti, Waldemar Bujalski, Arthur W. Etchells III, Alvin W. Nienow

Journal:

The Canadian Journal of Chemical Engineering

Year:

2003

Language:

english

File:

PDF, 537 KB

english, 2003

45

Fabrication by three-phase emulsification of pellicular adsorbents customised for liquid fluidised bed adsorption of bioproducts

Mohsen Jahanshahi, Andrzej W Pacek, Alvin W Nienow, Andrew Lyddiatt

Journal:

Journal of Chemical Technology & Biotechnology

Year:

2003

Language:

english

File:

PDF, 222 KB

english, 2003

46

The kinetics of mixing: stretching, chaos and transport,: J.M. Ottino Cambridge University Press, 1989, 364 pp.

Alvin W. Nienow

Journal:

International Journal of Heat and Fluid Flow

Year:

1991

Language:

english

File:

PDF, 273 KB

english, 1991

47

The effects of the azimuthal position of the measurement plane on the flow parameters determined by PIV within a stirred vessel

Antonio Guida, Alvin W. Nienow, Mostafa Barigou

Journal:

Chemical Engineering Science

Year:

2010

Language:

english

File:

PDF, 5.03 MB

english, 2010

48

Visualisation of bubble coalescence in a coalescence cell, a stirred tank and a bubble column

Kathryn Tse, Thomas Martin, Caroline M. Mcfarlane, Alvin W. Nienow

Journal:

Chemical Engineering Science

Year:

1998

Language:

english

File:

PDF, 866 KB

english, 1998

49

The effect of sodium caseinate concentration and processing conditions on bubble sizes and their break-up and coalescence in turbulent, batch air/aqueous dispersions at atmospheric and elevated pressures

Binjie Hu, Alvin W. Nienow, Andrzej W. Pacek

Journal:

Colloids and Surfaces B: Biointerfaces

Year:

2003

Language:

english

File:

PDF, 413 KB

english, 2003

50

CFD modelling of continuous precipitation of barium sulphate in a stirred tank

Zdzisław Jaworski, Alvin W Nienow

Journal:

Chemical Engineering Journal

Year:

2003

Language:

english

File:

PDF, 250 KB

english, 2003

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